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Contact

Centre for Gene Regulation & Expression
School of Life Sciences
University of Dundee
DD1 5EH Dundee
Scotland, United Kingdom
Angus' PA Carol Urquhart:
c.a.urquhart@dundee.ac.uk
College of Life Sciences, University of Dundee



Who we are


Professor Angus I. Lamond's Laboratory is part of the Centre for Gene Regulation & Expression,

in the School of Life Sciences University of Dundee


News


Launch of new University spin-out company Platinum Informatics Ltd from the Lamond Lab

platinum informatics logo

 

May 2018

Research in the Lamond Lab that has created powerful new software tools for management, visualisation and analysis of proteomics big data has led to the formation of a new Univeristy of Dundee Spin out company called Platinum Informatics

Platinum informatics has been awarded a SMART:SCOTLAND feasibility grant from Scottish Enterprise. The award will allow the development of a 'Processing Pipeline', a cloud-based 'Big Data' processing and analysis tool. This will further expand their suite of software for advanced data management. Platinum have also made the Converge Challenge Top 30. Converge Challenge is the leading, pan Scotland, company creation programme for staff, students and recent graduates of Scottish Universities and Research Institutes with the aim of creating a new generation of entrepreneurs in Scotland. We wish them every success in this entrepreneurial endeavour.

The press release can be viewed here and The Courier article here

May 2018

Members of the Lamond Lab (Tony Ly, Aki Endo, Alejandro Brenes, Vackar Afzal, Andrea Pawellek and Angus Lamond) have generated one of the most comprehensive analyses of the changes in the regulation and turnover of proteins in response to Src activation of cancer transformation published in Wellcome Open Research Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells. The signature of Src-responsive proteins is highly predictive of poor patient survival across multiple cancer types.

 ‘Volcano’ plots of –log10 p-value versus log2 fold change for the seven time points of Src activation, and cancer transformation.

Not only are these data available through the Wellcome Open Research portal but also through The Encyclopedia of Proteome Dynamics where you can investigate the effects of Src transformation on your proteins of interest.

April 2018

A collaboration with Professor Fiona Watt at Kings College London (Centre for Stem Cells & Regenerative Medicine), Tony Ly, Haru Yoshikawa, and Angus Lamond has shown the effect of stalled ribosomes on the homeostasis of the epidermis, An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis published in Nature.

"Different mRNA features can lead to ribosome stalling during translation elongation. Because the accumulation of stalled ribosomes on mRNAs is toxic, cells have evolved mechanisms to rescue and recycle stalled ribosomes by inducing their release and the degradation of the associated nascent polypeptides." A protein responsible for this rescue mechanism, Pelota (Pelo), when knocked out, resulted in loss of effective skin barrier function, scaly skin and epidermal thickening.

 




PepTracker
PepTracker provides management and mining capabilities for data generated during mass spectrometry studies.
Data Shop
Visualisation and statistical analysis tool for quantitative datasets
Proteomics Support
The Proteomics Support team have created a website that provides useful resources for proteomics studies.
Encyclopedia of Proteome Dynamics
A collection of multi-dimensional proteome properties from large-scale mass spectrometry experiments
Cell Biologist's Guide
The Cell Biologist's Guide to Proteomics provides information about mass spectrometry and experimentation.